Sodium Thiosulfate Injection is indicated for sequential use with sodium nitrite for the treatment of acute cyanide poisoning that is judged to be life-threatening. When the diagnosis of cyanide poisoning is uncertain, the potential risks associated with Sodium Thiosulfate Injection should be carefully weighed against the potential benefits, especially if the patient is not in extremis.
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IMPORTANT SAFETY INFORMATION
WARNINGS AND PRECAUTIONS
- Sulfites: Sodium thiosulfate may contain trace impurities of sodium sulfite. The presence of a trace amount of sulfites in this product should not deter administration of the drug for treatment of emergency situations, even if the patient is sulfite-sensitive.
Most common adverse reactions for sodium thiosulfate are:
USE IN SPECIFIC POPULATIONS
- Hypotension, headache, and disorientation
- Renal impairment: Sodium thiosulfate is substantially excreted by the kidney. The risk of toxic reactions to this drug may be greater in patients with impaired renal function.